Yes, Report Genie runs on Vista. However, please make sure you are setting the right directories for reports and logs.

Vista does not allow saving files to:
C:\Program Files\Report_Genie_Path. Yet Report Genie default locations for configuration file, logs and reports are under that directory.

So, in order to use Report Genie under Vista, you need to set Report Genie to use a writeable directory, such as: c:\temp. Of course, you need to create such a directory first.